Russell Tovey plays the lovable George, battling with his double identity as a mild-mannered and geeky hospital porter who for one night a month is transformed into a flesh-hungry, predatory werewolf.
Aidan Turner plays the good-looking and laid-back Mitchell who, in contrast to George, has the gift of the gab and an easy confidence with the ladies. But he is also a blood-sucking vampire struggling with going cold-turkey from the blood he craves.
Completing the flat-share trio is Annie, played by Lenora Crichlow, a talkative ghost lacking in self-confidence and desperate for company. Annie is still pining after her fiancé, whom she was due to marry before the fatal accident that left her with her ghostly affliction - and who happens to be the landlord of their flat.
The series follows the trio as they do their best to live their lives as normally as possible despite their strange and dark secrets.